AFC can be utilized in the prediction of ovarian response, but can not predict the oocyte/ embryo quality or the IVF outcome in an egg donation program.
Authors: Marco Melo, Nicolás Garrido, Claudio Alvarez, José Bellver, Marcos Meseguer, Antonio Pellicer, José Remohí.
(Fertility and Sterility 2009; 91: 148-156)
OBJECTIVE: The aim of this study was to verify whether the use of AFC could predict ovarian response, oocyte/embryo quality and IVF outcome.
DESIGN: Prospective study
SETTING: Instituto Universitario%u2014IVI, Valencia, Spain
PATIENTS: 1,074 donors and the respective 975 oocyte recipient cycles.
INTERVENTIONS: Controlled ovarian hyperstimulation (COH), endometrial preparation, IVF/ICSI, embryo transfer
MAIN OUTCOME MEASURES: COH and oocyte/embryo quality parameters, IVF outcome.
RESULTS: We observed lower E2 levels and fewer mature retrieved oocyte numbers among donors who showed AFC < 10 (p%u2264 0.001). These donors also showed significantly higher cancellation and no donation rates; poor and/or insufficient response was the principal cause (82%). However, there were no differences among the groups regarding embryo development parameters and IVF outcome. CONCLUSIONS: AFC is a non-invasive and simple tool that can improve the oocyte donor%u2019s selection of an egg donation program. This study suggests that AFC is a good predictor of ovarian response, but cannot be used to predict oocyte/embryo quality and IVF outcome.
KEYWORDS: antral follicle count/ controlled ovarian hyperstimulation/ embryo quality/ IVF outcome/ egg donation program/ oocyte quality/ ovarian response.