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Expression of p53, Ki-67, and CD31 Proteins in Endometrial Polyps of Postmenopausal Women Treated With Tamoxifen.

Data da publicação: 13/12/2010

Authors: Miranda SP, Traiman P, Cândido EB, Lages EL, Freitas GF, Lamaita RM, Vidigal PV, da Silva Filho AL.

(Int J Gynecol Cancer- 2010; 20(9):1525-30)

Abstract

This study was undertaken to investigate the expression of p53, Ki-67, and CD31 proteins in endometrial polyps of postmenopausal women treated with tamoxifen (TAM). Postmenopausal women with endometrial polyps treated with TAM (n = 20), postmenopausal women with endometrial polyps without hormone use (n = 20), postmenopausal women with atrophic endometrium (n = 20), and postmenopausal women with endometrial adenocarcinoma (n = 20) were prospectively investigated. Tissue samples were immunohistochemically evaluated by monoclonal antibodies for p53, Ki-67, and CD31.

The data were analyzed using the Student t test, analysis of variance, and χ2 to evaluate significant differences between the groups. The level of significance was set at
P < 0.05. There was no difference in the expression of p53 between the groups (P = 0.067). The expression of Ki-67 was higher in the polyp samples from TAM-treated women compared with those from the women using no hormone (P = 0.0047) and those from the women with atrophic endometrium (P = 0.008). Samples from the women with endometrial cancer was associated with higher Ki-67 expression compared with the polyp samples from TAM-treated women (P = 0.004). The expression of CD31 was higher in the polyp samples of TAMtreated women compared with that of the samples from the women with atrophic endometrium (P < 0.001) and similar to the polyp samples from the women using no hormone (P = 0.319) and to the samples from the women with endometrial cancer (P = 0.418). The use of TAM in postmenopausal women might be associated with increased cellular proliferation in endometrial polyps without interfering angiogenesis or inactivation of tumor suppressor proteins.



Texto revisado por:

Dr.Marco Melo / CRMMG 30246

Médico ginecologista. Membro da Comissão Nacional Especializada em Reprodução Humana-FEBRASGO, Mestre e Doutor em Ginecologia e Obstetrícia pela UFMG, Pós-doutor pelo Instituto Universitário-IVI, Universidade de Valência (Espanha), Especialização em Biologia Molecular da Implantação Embrionária pelo FIVIER (Espanha), Master em Ginecologia Endócrina e Reprodução Humana pelo Instituto Valenciano de Infertilidade (Espanha), Editor da Revista Cadernos de Medicina, Membro da Câmara Técnica de Reprodução Humana do CRM-MG. CRMMG 30246

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